Why NAD+ is called the body's metabolic molecule
Every moment begins inside your cells. Right now, while you're reading this, billions of cells are working silently in the background. Your heart i...
Longevity Pen®
The Longevity Protocol - Refill Duo
- ✓N-Core 500 (NAD⁺) powers your cells. S-Core 200 (spermidine) renews them.
- ✓Two compounds acting on opposite ends of the same autophagy switch.
- ✓Both pillars in one refill — engineered for your Longevity Pen®.
- ✓GMP-grade, manufactured in Europe.
Two pillars. One protocol. One purpose. New to the Pen? Start with the Longevity Protocol Starter Kit.
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- €470,00
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- €470,00
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The Longevity Protocol
Why both pillars — NAD⁺ alone vs Spermidine alone vs the full protocol
Longevity Protocol
NAD⁺ alone
Spermidine alone
Supports cellular energy (mitochondrial function)
Supports cellular renewal (autophagy induction)
Powers SIRT1 to remove the acetyl brake on autophagy
Blocks EP300 from adding the acetyl brake
Covers both ends of the acetylation switch
This information is sourced from scientific studies, clinical trials, and reputable health platforms.
Pillar One — N-Core 500: the science behind NAD⁺
NAD⁺ is the coenzyme at the centre of mitochondrial energy metabolism. Levels decline with age. N-Core 500 delivers 500 mg of high-purity NAD⁺ per cartridge — 10 micro-doses of 50 mg.
Cellular Energy: Boost ATP production at the source
NAD⁺ is essential for mitochondrial energy metabolism. Supplementation restores depleted NAD⁺ levels, enhancing mitochondrial function and cellular energy output.
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DNA Repair: Support genome integrity & longevity
NAD⁺ activates PARP enzymes and sirtuins, key players in cellular repair and healthy aging.
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Cognitive Function: Protect memory and brain resilience
NAD⁺ levels are linked to neuronal health, synaptic plasticity and neuroprotection. Supplementation has shown improvements in cognition and memory retention.
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Cardiovascular Health: Support vascular flexibility and function
NAD⁺ improves endothelial function and increases nitric oxide bioavailability, contributing to better blood flow and heart health.
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Pillar Two — S-Core 200: the science behind spermidine
Spermidine is a natural polyamine central to autophagy — the body’s cellular recycling and renewal system. S-Core 200 delivers 200 mg of high-concentration spermidine per cartridge — a daily micro-dose of 8–9.6 mg (10–12 pen units), roughly 20–25 doses.
Cellular Renewal: Activate autophagy, your cells’ clean-up system
Spermidine is one of the most-studied natural inducers of autophagy — the process cells use to recycle and renew damaged components — and extended lifespan across multiple organisms in landmark research.
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Cardiovascular Health: Support heart function and healthy blood pressure
Spermidine supplementation enhanced cardiac autophagy and mitochondrial function, and higher dietary intake is associated with lower blood pressure and reduced cardiovascular risk in humans.
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Cognitive Function: Support memory and brain resilience
In a randomized controlled trial, spermidine supplementation was associated with improved memory performance in older adults at risk for dementia.
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Healthy Aging & Longevity: Linked to a longer, healthier life
Across a 20-year population study, spermidine showed the strongest inverse association with mortality of 146 nutrients analysed — comparable to being about 5.7 years younger.
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Why both: two pillars, one switch
All claims below are based on peer-reviewed research. The Longevity Protocol combines NAD⁺ and spermidine — two compounds that support cellular energy and cellular renewal through distinct but converging biological pathways.
One Switch, Two Keys: how cellular renewal is turned on
Autophagy is controlled by the acetylation state of its core proteins. Spermidine and sirtuin-dependent compounds induce autophagy through distinct pathways that converge on the acetylproteome — different entry points to the same switch.
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NAD⁺ Powers the Eraser
SIRT1 forms a complex with the core autophagy proteins ATG5, ATG7 and ATG8 and deacetylates them in an NAD⁺-dependent fashion. Without NAD⁺, this arm of the switch cannot operate.
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Spermidine Blocks the Writer
EP300 is the acetyltransferase that adds the acetyl groups keeping autophagy off — acetylating ATG5, ATG7, ATG12 and LC3. Spermidine acts as a competitive inhibitor of EP300, releasing that brake.
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Renewal Runs on Energy
Spermidine's cardioprotective and lifespan effects depend on autophagy — they disappear in animals lacking the autophagy protein Atg5. Renewal is an active, energy-requiring process, not a passive one.
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Energy at the Source
NAD⁺ is essential to mitochondrial energy metabolism. Restoring depleted NAD⁺ enhances mitochondrial function and cellular energy output — the fuel every maintenance process draws on.
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Two Caloric-Restriction Mimetics, One Protocol
Spermidine is described as a natural autophagy inducer reproducing many healthful effects of caloric restriction. Paired with NAD⁺, the protocol addresses two distinct hallmarks of aging — energy decline and loss of proteostasis.
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FAQ
It combines the two pillars of the Longevity Pen® platform: N-Core 500 (NAD⁺) for cellular energy and S-Core 200 (spermidine) for cellular renewal — delivered as daily micro-doses from a single reusable pen.
They support different biological systems that depend on each other. NAD⁺ underpins the energy your cells run on; spermidine supports the maintenance and recycling systems that keep cells in good working order. In published research the two act on opposite ends of the same molecular switch that controls autophagy — spermidine blocks the enzyme that switches it off, while NAD⁺ powers the enzyme that switches it on.
Each compound is independently supported by peer-reviewed research. The rationale for combining them is mechanistic and based on published biology — we do not claim a proven combined effect. We'd encourage you to read the studies linked above and speak with a healthcare professional.
Yes. The Longevity Pen® is reusable, and both N-Core 500 and S-Core 200 cartridges are engineered for it. Swap cartridges as your protocol requires.
They run in parallel and can be taken on the same day — simply swap the cartridge in your pen. S-Core 200 (spermidine) is a daily shot at 10–12 pen units (8 mg – 9.6 mg) for 20 days, then 10 days off. N-Core 500 (NAD⁺) is one 50 mg shot every second or third day. Always consult your doctor to determine the exact dosage that is right for your body.
Yes. Store both in the provided case with the included ice pack, or in the refrigerator when not in use. Do not freeze.
Yes, the Longevity Pen® is compact and portable. It comes with a travel-friendly case and ice pack. However, check airline regulations for devices with injectable components.
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