Why Spermidine deserves a spot in your wellness routine?
What is Spermidine? Spermidine is a naturally occurring polyamine found in every cell of your body. It's involved in key processes related to cell ...
Vitality with ease
Wellness should be simple, effective, and empowering. Our innovative microdosing pen combines cutting-edge science with convenience, putting compounds like NAD+ and spermidine directly in your hands and your own comfort. With results you can trust and a process as easy as click-and-go, it’s backed by high-quality ingredients and rigorous standards.
Convenience
Enjoy microdosing from the comfort of home with no hassle — it’s as easy as click-and-go.
Safety & Quality
Crafted in state-of-the-art facilities for unmatched safety and quality
Innovation
Experience precision dosing with a sleek, modern design.
Personalized wellness
Maintain energy, focus, and vitality with ease.
Pillar one: cellular energy
What NAD+ does inside your cells
NAD+ is a coenzyme present in every cell in your body. It sits at the centre of how cells convert fuel into usable energy, and the repair enzymes that keep DNA intact draw on it every time they work. Understanding what it does is more useful than any promise about how you will feel.
Energy metabolism
NAD+ carries electrons through the reactions that produce ATP, the cell's usable energy currency.
DNA repair
PARP enzymes detect and patch damaged DNA. Each repair consumes NAD+.
Sirtuin activity
Sirtuins, the regulatory proteins involved in cellular stress response, cannot function without NAD+.
Delivered directly
The N-Core 500 cartridge delivers 500 mg subcutaneously in ten micro-doses of 50 mg, bypassing digestion entirely.
Pillar two: cellular renewal
What spermidine does inside your cells
Spermidine is a polyamine your body produces on its own and also takes in through food. It is the compound most closely tied to autophagy, the process cells use to break down and recycle what is worn out. Your own production of it declines with age, and so does the amount in most modern diets.
Autophagy
Spermidine is one of the few naturally occurring compounds shown to trigger the cell's own recycling program.
Epigenetic regulation
It works by inhibiting acetyltransferases, the enzymes that control which genes are switched on.
Present in every cell
Found throughout the human body and in almost every organism studied, from yeast to humans.
Delivered directly
The S-Core 200 cartridge delivers 200 mg, trehalose-stabilised, in a daily micro-dose of 8 to 9.6 mg.
NAD+ powers your cells. Spermidine renews them.
Two compounds, two pathways, one pen.
how it works
Wellness made simple
1
Step 1
Load your ingredient cartridge with ease.
2
Step 2
Microdose in seconds with precision technology.
3
Step 3
Feel energized every day - at work, home, or the gym.
Reignite the energy your body was born with
Our Starter Kit
- Regular price
- €534,00
- Sale price
- €534,00
- Regular price
-
€0,00
Tax included.
- ✓N-Core 500 (NAD⁺) powers your cells. S-Core 200 (spermidine) renews them.
- ✓Two compounds acting on opposite ends of the same autophagy switch.
- ✓Bypasses digestion — faster and more direct than tablets or powder.
Two pillars. One protocol. One purpose. Already own a Pen? Explore the Longevity Protocol Refill Duo.
What our customers are saying
Microdosing with the Longevity Pen®
Comparison between Injections, Powder, and Tablets
Longevity Pen
Tablets
Powder
Fast absorption
High bioavailability
Immediate effect on cellular metabolism
Avoids digestive issues
Convenient for daily use
This information is sourced from scientific studies, clinical trials, and reputable health platforms.
Blogs
Insights for a healthier you
Why your energy levels drop with age (and how to fix It)
If you’ve noticed that you don’t have the same energy you once did, you’re not alone. Many people experience age-related fatigue, struggling with l...
Why NAD+ is called the body's metabolic molecule
Every moment begins inside your cells. Right now, while you're reading this, billions of cells are working silently in the background. Your heart i...
Not all NAD+ is created equal
NAD+ may look like a single ingredient name, but the story behind the molecule matters. Discover where Longevity Pen’s NAD+ comes from, how it is p...
Longevity Pen NAD+ Certificate of Analysis: What this COA shows
At Longevity Pen, we believe quality should be visible, understandable and verifiable. That is why every important product conversation should go b...
Safe subcutaneous use starts with formulation
Subcutaneous use is becoming more visible. Once mainly associated with treatments such as insulin, subcutaneous injections are now used across a gr...
Frequently Asked Questions
Answers & Questions
From basic inquiries to intricate details, we've collated the most common queries from our user base.
The Longevity Pen® is a reusable microdose delivery device designed for at-home use. It delivers precise doses of compounds like NAD+ and spermidine subcutaneously, bypassing the digestive system.
Insert a cartridge, prepare the site with an alcohol wipe, set your dose and press. The pen handles the rest. Each cartridge is pre-filled and engineered specifically for the device, so there is no measuring or mixing.
The pen is designed for self-administration and comes with clear step-by-step instructions and a short instruction video. All cartridges are manufactured in Europe to GMP-grade standards. If you have an existing medical condition or take medication, speak to a healthcare professional before starting.
Oral supplements pass through the digestive system before anything reaches the bloodstream. Subcutaneous delivery bypasses digestion entirely, which is the main practical difference between the two routes.
Yes. The pen comes with a portable case and ice pack to keep cartridges cool. Check airline and destination rules for carrying needles and medical devices before you fly.
They contain different compounds and sit on different sides of cellular health. N-Core 500 contains 500 mg of NAD+, the coenzyme central to how cells produce energy and repair DNA. S-Core 200 contains 200 mg of spermidine, the polyamine most closely associated with autophagy, the cell's recycling process. Both are engineered for the same pen.
NAD+ is a coenzyme found in every cell in your body. It carries electrons through the reactions that produce ATP, and the PARP enzymes that repair DNA consume it each time they work. Sirtuins, a family of regulatory proteins, also depend on it.
Spermidine is a polyamine your body produces and also takes in through food, with wheat germ and fermented soy among the richest sources. It is one of the few naturally occurring compounds shown to induce autophagy, the process cells use to break down and recycle worn components.
Yes. They act through different pathways, which is why we offer them as a combined protocol. The Longevity Protocol Starter Kit includes one cartridge of each, and the Refill Duo restocks both.
Every Starter Kit includes the reusable Longevity Pen®, a portable case with ice pack, 10 needles and 10 alcohol wipes. The NAD+ kit adds one N-Core 500 cartridge (500 mg), the Spermidine kit adds one S-Core 200 cartridge (200 mg), and The Longevity Protocol includes one of each.
The N-Core 500 contains 500 mg, divided into ten micro-doses of 50 mg. The S-Core 200 contains 200 mg in 2.5 mL, with a daily micro-dose of 8 to 9.6 mg, roughly a twenty-day cycle.
Keep cartridges in the supplied case with the ice pack when you are out. For longer storage keep them cool in the refrigerator. The S-Core 200 is trehalose-stabilised and filled under inert gas; both cartridges are free from preservatives.
Adults who want to take NAD+ or spermidine without visiting a clinic. It is not suitable if you are pregnant or breastfeeding, and if you have a medical condition or take medication you should speak to a healthcare professional first.
Stop using the pen and consult a healthcare professional. You can also contact us at support@longevitypen.com so we can log it.